According to the city of Beaufort, Town of Port Royal Fire Department crews responded to Highway 1-70 around 7:00 a.m. on Saturday morning.
Officials say a full-sized van collided with a semi-tractor trailer resulting in the entire front of the van, including the passenger area lodging underneath the tractor-trailer.
The van caught on fire and three people were trapped inside. After an hour, crews put the fire out, extricated all three passengers.
Two were air flighted to nearby trauma centers and one passenger died.
Nine fire departments, three ground EMS units, two air ambulance helicopters, and nearly thirty-five emergency workers responded.