Greenville County Coroner Jeff Fowler confirmed that two people died following the crash.
Greenville City Fire spokesperson Tristan Johnson confirmed that the two people who died were the pilot and the co-pilot of the plane.
Johnson said that the two people injured in the crash are married and are currently in critical condition.
Greenville Memorial Hospital officials said three people were taken to the hospital following the crash.
According to Greenville Police Department spokesperson Donnie Porter, the call about the crash came in around 1:40 p.m. Porter said the plane ran off the runway and crashed.
According to a Greenville Police Department Twitter post, the roads surrounding the south side of the airport are blocked off.
An app alert from Greenville Police Department said the
Roads surrounding the south side of the airport are currently blocked off, as an aircraft went off the runway and crashed onto Airport Road. The call came in around 1:30p.m. GPD is assisting GCFD and EMS. More details to follow. #gvlpd pic.twitter.com/822ZSHkxoA— Greenville SC Police (@GvlPD) September 27, 2018